Electrical Microstimulation & fMRI

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Mapping Cortical Activity Elicited with Electrical Microstimulation Using fMRI in the Macaque

Over the last two centuries, electrical microstimulation has been used to demonstrate causal links between neural activity and specific behaviors and cognitive functions. However, to establish these links it is imperative to characterize the cortical activity patterns that are elicited by stimulation locally around the electrode and in other functionally connected areas. We have developed a tec...

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Behavioral Detection of Electrical Microstimulation in Different Cortical Visual Areas

The extent to which areas in the visual cerebral cortex differ in their ability to support perceptions has been the subject of considerable speculation. Experiments examining the activity of individual neurons have suggested that activity in later stages of the visual cortex is more closely linked to perception than that in earlier stages [1-9]. In contrast, results from functional imaging, tra...

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Optogenetic and Electrical Microstimulation Systematically Bias Visuospatial Choice in Primates

Optogenetics is a recently developed method in which neurons are genetically modified to express membrane proteins sensitive to light, enabling precisely targeted control of neural activity [1-3]. The temporal and spatial precision afforded by neural stimulation by light holds promise as a powerful alternative to current methods of neural control, which rely predominantly on electrical and phar...

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Current approaches to model extracellular electrical neural microstimulation

Nowadays, high-density microelectrode arrays provide unprecedented possibilities to precisely activate spatially well-controlled central nervous system (CNS) areas. However, this requires optimizing stimulating devices, which in turn requires a good understanding of the effects of microstimulation on cells and tissues. In this context, modeling approaches provide flexible ways to predict the ou...

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Electrical Microstimulation of the Superior Colliculus in Strabismic Monkeys

PURPOSE Visually guided saccades are disconjugate in human and nonhuman strabismic primates. The superior colliculus (SC) is a region of the brain topographically organized in visual and motor maps where the saccade goal is spatially coded. The present study was designed to investigate if a site of stimulation on the topographic motor map was evoking similar or different saccade vectors for eac...

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ژورنال

عنوان ژورنال: Frontiers in Behavioral Neuroscience

سال: 2009

ISSN: 1662-5153

DOI: 10.3389/conf.neuro.08.2009.09.005